Numerous biological processes harvest out-of-equilibrium forces for transport, sensing, signaling and more. For example, pumping of ions is performed within fluctuating pores that are believed to facilitate transport. The nature of these forces is extremely diverse, from electrical driving to thermodynamic or chemical driving. The ability to describe nonequilibrium states is critical to understand numerous biological processes but is extremely challenging as standard thermodynamic concepts fail. The MolecularControl project will investigate out-of-equilibrium systems relevant to health issues or sustainable energy. It plans to develop theoretical tools that can be widely applied, and transferred to other soft matter problems.